Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products
نویسندگان
چکیده
منابع مشابه
Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products.
Dynamic nuclear polarization and dissolution of a (13)C-labeled substrate enables the dynamic imaging of cellular metabolism. Spectroscopic information is typically acquired, making the acquisition of dynamic volumetric data a challenge. To enable rapid volumetric imaging, a spectral-spatial excitation pulse was designed to excite a single line of the carbon spectrum. With only a single resonan...
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PURPOSE Metabolic imaging with hyperpolarized 13 C-labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses that can be used. We describe here a single-shot three-dimensional (3D) imaging sequence and demonstra...
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GE Healthcare, Menlo Park, California, USA. GE Healthcare, Toronto, Canada. GE Healthcare, Denmark. *Address reprint requests to: R.E.H., GE Healthcare, 333 Ravenswood Ave., Menlo Park, CA 94025. E-mail: [email protected] Received November 15, 2011; Accepted June 10, 2012. DOI 10.1002/jmri.23753 View this article online at wileyonlinelibrary.com. This article is accredited as a journal-based CM...
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Introduction: The stimulated-echo (STE) can be used to provide high sensitivity to diffusion and flow (1). We have recently applied a STE acquisition mode (STEAM) to hyperpolarized [1-C]pyruvate metabolic imaging and found improved tumor contrast (2). The STE distinguishes whether [1-C]pyruvate is converted to [1-C]lactate within the tissue or whether the [1-C]lactate was produced elsewhere and...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance
سال: 2008
ISSN: 1090-7807
DOI: 10.1016/j.jmr.2008.03.012